South America is a vast continent with lots of incredible cities to explore. Spring in the Northern Hemisphere is Fall in the Southern Hemisphere which means that this spring for North Americans, there are lots of opportunities to experience spring in Colombia and parts of Ecuador and fall in most other places in South America.

Between March to June, these are some of the cities travelers won’t want to miss in South America. Plus, find out where to stay when visiting.

10 Lima, Peru

Lima is often viewed as a necessary stopover on the way to Cusco and Machu Picchu for people visiting Peru, but the capital has so much more to offer. As the culinary capital of South America, Lima has some of the best restaurants in the entire world. Travelers will want to base themselves in the neighborhood of Miraflores during their stay and be sure to book a food tour. Temperatures begin to cool off a bit in Lima starting mid-April when summer ends, and fall begins.

9 Buenos Aires, Argentina

Buenos Aires is the capital of Argentina and offers exceptional cuisine, plus lively nightlife. Colorful neighborhoods like La Boca and dance classes in the Argentine Tango are some of the top reasons to visit. March to June is fall in Buenos Aires meaning the humidity of the summer dissipates and temperatures are more pleasant during the daytime. It’s the ideal time to explore! Be sure to stay in a reputable area of the city like Palermo, Recoleta, or San Telmo.

8 Cuenca, Ecuador

Many travelers go to Ecuador to visit Quito or Guayaquil, but Cuenca is quickly gaining traction as one of the most interesting cities in the country. Located in the southern Andes Mountains, Cuenca sits on the Tomebamba River and has lots of beautiful streets with shops selling local crafts and other products. Stunning architecture and the impressive surrounding landscapes add to Cuenca’s allure. Cuenca’s fall season runs from March to June, so travelers can anticipate cooler temperatures and cloudy skies. This is the perfect weather for exploring the city without the humidity.

Related: 10 Of The Most Naturally Beautiful Destinations In South America

7 Santiago, Chile

Santiago is the capital of Chile and is a vast city that is surrounded by the snow-capped peaks of the Andes Mountain range. As one of the largest cities in the Americas, Santiago de Chile offers plenty to do and see.

6 Cartagena, Colombia

Colombia is located in the Northern Hemisphere, so March to June is spring in Cartagena. Spring is the ideal time to visit Cartagena and its gorgeous beaches because temperatures are hot and there are very few days of rain each month. A one-week vacation in Cartagena, Colombia, should be on travelers' bucket lists.

Related: 11 Important Tips For First-Timers Visiting Colombia

5 Sucre, Bolivia

Many people don’t realize that Bolivia has two capital cities, La Paz and Sucre. While most people have heard of La Paz, Sucre flies under the radar. It’s located in Bolivia’s Southern Highlands and is a visually beautiful destination with whitewashed buildings. Fall in Bolivia runs from March to June and is the perfect time to visit Sucre for moderate temperatures and almost no rainfall.

4 Colonia Del Sacramento, Uruguay

Located in southwestern Uruguay, Colonia del Sacramento is worth visiting on any trip to South America. It can be reached by boat from Buenos Aires, making it a great day trip option for people visiting Argentina as well. March to June in Uruguay is fall, with temperatures in March remaining warm (day time high around 22ºC) but decreasing into June. There is minimal rainfall, with 5–6 days of rain per month on average.

3 Mendoza, Argentina

Mendoza is another beautiful Argentinian city with plenty to offer travelers in the North American spring season. It’s fall in Mendoza from March to June, which means it's the harvest season for the many vineyards in this region.

Related: 12 Tips For Solo Female Travel Throughout South America

2 Arequipa, Peru

Arequipa is a hidden gem of Peru that is worth visiting in addition to Lima and Cusco. Travelers will love the colonial-era city’s architecture and unique cuisine, which differs from other parts of Peru. March to June is the perfect time to visit Arequipa for warm temperatures and clear skies.

1 Medellín, Colombia

Medellín is known as the City of Eternal Spring, so travelers don’t need to visit in spring to experience the city’s beautiful weather. The city has a challenging past but has made great strides in recent decades and now is a tourism hub for Colombia. Walking tours of Comuna 13 are the perfect way to learn about the history of Medellín. El Poblado is a lively neighborhood where tourists will want to stay.